John J Lemasters Selected Research

Liver Transplantation

1/2018	Ischemic preconditioning attenuates acute lung injury after partial liver transplantation.
1/2017	8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation.
7/2015	Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice.
1/2012	Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
1/2012	Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811.
5/2008	Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts.
1/2008	Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition.
8/2004	Role of free radicals in failure of fatty liver grafts caused by ethanol.
5/2004	Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats.

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John J Lemasters Research Topics

Disease

46	Necrosis 11/2023 - 02/2002
24	Mitochondrial Diseases (Mitochondrial Disease) 04/2023 - 02/2002
19	Ischemia 01/2022 - 10/2002
17	Neoplasms (Cancer) 01/2021 - 02/2006
13	Reperfusion Injury 04/2023 - 05/2002
10	Hypoxia (Hypoxemia) 11/2020 - 02/2006
9	Inflammation (Inflammations) 01/2022 - 10/2003
9	Fibrosis (Cirrhosis) 12/2019 - 11/2003
7	Hemorrhage 09/2014 - 03/2003
6	Hepatocellular Carcinoma (Hepatoma) 11/2020 - 12/2002
6	Fatty Liver 01/2017 - 05/2004
6	Hemorrhagic Shock 09/2014 - 04/2003
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016 - 11/2003
4	Hyperbilirubinemia 01/2017 - 02/2011
3	Alcoholic Liver Diseases (Alcoholic Liver Disease) 11/2022 - 09/2018
3	Liver Failure 11/2018 - 11/2004
3	Hepatitis 11/2018 - 02/2002
3	Body Weight (Weight, Body) 01/2018 - 08/2010
3	Myocardial Infarction 03/2014 - 11/2008
3	Liver Diseases (Liver Disease) 08/2013 - 02/2006
3	Cholestasis 12/2008 - 11/2003
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022 - 02/2011
2	Ventricular Remodeling 03/2014 - 01/2014
2	Atrophy 01/2014 - 11/2006
2	Multiple Organ Failure (MODS) 01/2012 - 08/2010

Drug/Important Bio-Agent (IBA)

18	Alanine Transaminase (SGPT)IBA 01/2022 - 08/2004
16	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2023 - 11/2004
14	Adenosine Triphosphate (ATP)IBA 01/2021 - 02/2002
9	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 11/2003
8	IronIBA 01/2022 - 11/2008
8	Ethanol (Ethyl Alcohol)IBA 11/2018 - 05/2004
8	TubulinIBA 01/2018 - 12/2010
8	Oxygen (Dioxygen)IBA 02/2011 - 04/2003
7	Minocycline (Cyclops)FDA LinkGeneric 10/2023 - 01/2008
7	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/2014 - 10/2002
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 10/2002
5	Glutathione (Reduced Glutathione)IBA 01/2018 - 11/2004
5	Caspase 3 (Caspase-3)IBA 09/2014 - 07/2003
5	BilirubinIBA 02/2013 - 05/2008
5	CytokinesIBA 01/2012 - 10/2003
4	Voltage-Dependent Anion ChannelsIBA 11/2022 - 09/2012
4	erastinIBA 01/2018 - 04/2013
4	BuffersIBA 04/2012 - 06/2004
4	(melle-4)cyclosporinIBA 01/2012 - 01/2008
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012 - 10/2002
4	PolyphenolsIBA 08/2010 - 11/2003
4	Free RadicalsIBA 05/2008 - 07/2003
3	JNK Mitogen-Activated Protein KinasesIBA 04/2023 - 01/2012
3	AcetaldehydeIBA 11/2022 - 02/2006
3	Mitochondrial DNA (mtDNA)IBA 11/2022 - 02/2002
3	Peroxynitrous Acid (Peroxynitrite)IBA 01/2022 - 07/2010
3	Deferoxamine (Desferal)FDA LinkGeneric 01/2022 - 10/2013
3	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 01/2022 - 09/2006
3	Superoxides (Superoxide)IBA 01/2022 - 04/2003
3	Adenosine Diphosphate (ADP)IBA 01/2021 - 01/2016
3	AntioxidantsIBA 01/2018 - 08/2004
3	Acetylcysteine (Siran)FDA LinkGeneric 01/2018 - 11/2006
3	Adenine NucleotidesIBA 10/2017 - 04/2013
3	Protein Isoforms (Isoforms)IBA 01/2016 - 07/2003
3	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 09/2014 - 10/2003
3	DNA (Deoxyribonucleic Acid)IBA 09/2014 - 10/2003
3	Tetracycline (Achromycin)FDA LinkGeneric 09/2014 - 01/2012
3	Photosensitizing Agents (Photosensitizers)IBA 01/2013 - 07/2009
3	HEPESIBA 04/2012 - 06/2004
3	Oxidants (Oxidizing Agents)IBA 08/2011 - 08/2004
3	Phosphotransferases (Kinase)IBA 09/2006 - 06/2004
2	CeramidesIBA 02/2024 - 10/2012
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2023 - 01/2022
2	Histone Deacetylase InhibitorsIBA 04/2023 - 01/2018
2	tetramethylrhodamine (T 489)IBA 11/2022 - 12/2010
2	Propidium (Propidium Iodide)IBA 11/2022 - 11/2013
2	Alanine (L-Alanine)FDA Link 01/2022 - 11/2006
2	TransferasesIBA 01/2022 - 11/2006
2	AldehydesIBA 01/2020 - 12/2019
2	Starch (Cornstarch)IBA 01/2020 - 10/2013
2	mitoquinoneIBA 01/2018 - 01/2016
2	EnzymesIBA 01/2018 - 09/2014
2	AcidsIBA 01/2018 - 04/2007
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2018 - 10/2010
2	Peroxidase (Myeloperoxidase)IBA 01/2015 - 11/2006
2	Doxycycline (Periostat)FDA LinkGeneric 09/2014 - 11/2013
2	Ringer's SolutionIBA 09/2014 - 05/2002
2	Ru 360IBA 11/2013 - 10/2013
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2013 - 07/2009
2	phthalocyanineIBA 03/2012 - 07/2009
2	ChemokinesIBA 01/2012 - 10/2003
2	Mitogen-Activated Protein Kinase 9IBA 01/2012 - 05/2008
2	Messenger RNA (mRNA)IBA 01/2012 - 10/2002
2	SphingosineIBA 01/2012 - 01/2012
2	3-nitrotyrosineIBA 02/2011 - 07/2010
2	NitrogenIBA 08/2010 - 02/2006
2	Reactive Nitrogen SpeciesIBA 08/2010 - 04/2003
2	Superoxide DismutaseIBA 05/2008 - 07/2003
2	antiarrhythmic peptide (AAP)IBA 11/2006 - 08/2004

Therapy/Procedure

10	Transplantation 01/2017 - 03/2002
9	Liver Transplantation 01/2018 - 05/2004
6	Resuscitation 09/2014 - 04/2003
5	Ligation 12/2019 - 10/2002
5	Therapeutics 01/2016 - 02/2006
3	Photochemotherapy (Photodynamic Therapy) 01/2013 - 07/2009